IL1RAP

interleukin 1 receptor accessory protein

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

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Products

Antibodies (48)

Proteins (17)

ELISA Kits (5)

Type

Over-Expression Lysate (6)

Primary (48)

Recombinant (11)

Sandwich (3)

Sandwich CLIA (2)

Target

IL1RAP (70)

Reactivity

Human (43)

Mouse (16)

Rat (5)

Bovine (8)

Application

IHC (3)

IHC-P (2)

WB (38)

Flo (4)

ELISA (10)

ICC (2)

IF (1)

Peptide-ELISA (1)

Host

rabbit (42)

mouse (6)

Isotype

IgG (14)

IgG1 (1)

IgG2a (1)

IgG2a,k (1)

Clonality

monoclonal mc (6)

polyclonal pc (42)

Clone

04 (1)

3D9 (1)

Format

96-Well Strip Plate (4)

AP Conjugated (1)

APC (3)

APC Conjugated (5)

Biotin Conjugated (4)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (5)

HRP Conjugated (4)

PE Conjugated (5)

Preservative Free (1)

Unconjugated (18)

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Epitope

aa21-367 (8)

aa420-558 (8)

aa65-249 (8)

C-Terminus (1)

aa21-356 (1)

aa517-543 (1)

Publications

No (70)

Sample Type

Cell Culture Supernatants (1)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (4)

Serum (5)

Tissue Homogenates (2)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

Fc/6His,C-terminus (1)

Fc-6His, C-terminus (1)

GST (1)

His (3)

His,C-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (13)

Mouse (1)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Human (1)

Human Cells (3)

Mammalian Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (6)

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IL1RAP Antibody (aa21-356) LS-C379744

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (aa21-356) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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IL1RAP Antibody (aa21-367) LS-C373612

Antibody:

IL1RAP Rabbit anti-Mouse Polyclonal (aa21-367) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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IL1RAP Antibody (aa21-367, Biotin) LS-C689050

Antibody:

IL1RAP Rabbit anti-Mouse Polyclonal (aa21-367) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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IL1RAP Antibody (aa21-367, FITC) LS-C424600

Antibody:

IL1RAP Rabbit anti-Mouse Polyclonal (aa21-367) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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IL1RAP Antibody (aa21-367, PE) LS-C728094

Antibody:

IL1RAP Rabbit anti-Mouse Polyclonal (aa21-367) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• Biotin
• FITC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • PE

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IL1RAP Antibody LS-C311

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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Human IL1RAP (Sandwich ELISA) ELISA Kit - LS-F6689

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Mouse IL1RAP (Sandwich ELISA) ELISA Kit - LS-F6942

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$854

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IL1RAP Antibody (clone 3D9) LS-C197511

Antibody:

IL1RAP Mouse anti-Human Monoclonal (3D9) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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IL1RAP Antibody (APC) LS-C487499

Antibody:

IL1RAP Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

25 Tests/$293; 100 Tests/$376

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Mouse IL1RAP Protein (Recombinant 6His, N-terminus) (aa21-367) - LS-G25928

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

43.7 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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IL1RAP Antibody LS-C310

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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IL1RAP Antibody (C-Terminus) LS-C757849

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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IL1RAP Antibody LS-C831590

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

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IL1RAP Antibody (AP) LS-C408826

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (AP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

AP Conjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IL1RAP Antibody (aa517-543) LS-C809110

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (aa517-543) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IL1RAP Antibody (PE) LS-C487503

Antibody:

IL1RAP Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$293; 100 Tests/$376

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IL1RAP Antibody LS-C482427

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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IL1RAP Antibody (aa65-249, Biotin) LS-C297823

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (aa65-249) (Biotin) Antibody

Reactivity:

Bovine, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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Mouse IL1RAP (CLIA) ELISA Kit - LS-F26231

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

2.74 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$990

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IL1RAP Antibody LS-C487505

Antibody:

IL1RAP Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

20 µl/$271; 100 µl/$412

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IL1RAP Antibody LS-C487501

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

IL1RAP Antibody (aa420-558) LS-C373617

Antibody:

IL1RAP Rabbit anti-Human Polyclonal (aa420-558) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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IL1RAP Antibody (clone 04, Preservative Free) LS-C819997

Antibody:

IL1RAP Mouse anti-Human Monoclonal (Preservative Free) (04) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$286; 100 µl/$435

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IL1RAP Antibody LS-C487500

Antibody:

IL1RAP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

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