Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone Reg20] (IgG2a) to Mouse IL1R1
Western blot, Immunoprecipitation
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [Reg20]
Specificity and Use
For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
IL1R1 Antibody, Antigen CD121a Antibody, D2S1473 Antibody, IL-1R-1 Antibody, IL-1R-alpha Antibody, IL-1RT-1 Antibody, IL-1RT1 Antibody, IL1R Antibody, IL1RA Antibody, IL1RT1 Antibody, Interleukin receptor 1 Antibody, Interleukin-1 receptor alpha Antibody, Interleukin-1 receptor type 1 Antibody, CD121A Antibody, CD121a antigen Antibody, Interleukin 1 receptor, type I Antibody, Interleukin-1 receptor type I Antibody, Interleukin-1 type i receptor Antibody, p80 Antibody
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.