Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
IL16 antibody was raised against synthetic peptide located between aa76-125 of human IL16 (Q8IUU6). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Marmoset, Guinea pig (100%); Elephant (85%).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Short term, +4°C. Long term, add glycerol to 40-50%, aliquot to avoid freeze/thaw cycles, and store at -20°C. Sensitive to light.
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.Isoform 3 is involved in cell cycle progression in T-cells.