Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
IL11 antibody was raised against recombinant human IL-11.
Recognizes human IL-11.
Suitable for use in ELISA and Neutralization. ELISA (Sandwich): 8-9 ug/ml (100 ul/well), Detects >0.2 ng/well of recombinant human IL-11. Neutralization: 2.4-3.6 ug/ml Yields one-half maximal inhibition [ND50] of the biological activity of hIL-11 (5.0 ng/ml).
Lyophilized from PBS
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066).