Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Human IL-1B / IL-1 Beta
Human IL-1B / IL-1 Beta
Human (tested or 100% immunogen sequence identity)
Ion exchange chromatography
Specificity and Use
IL-1B / IL-1 Beta antibody was raised against recombinant human IL-1b.
Recognizes human IL-1b.
Direct ELISA. Direct ELISA: 1:10000 dilution will yield 0.2 O. D. using alkaline phosphatase conjugated rabbit anti-mouse Ig. A 1:2000 dilution will completely inhibit a thymocyte co-stimulation assay using suboptimal doses of Concanavalin A.
500 µl deionized water
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.