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Anti-IL-10 Antibody LS-C43003

Ordering

Wt. Vol. Conc. Price
100 µg 100 µl 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular IL-10 Antibodies

Anti-IL-10 Antibody (clone JES5-2A5) IHC-plus™ LS-B4913
Rat Monoclonal [clone JES5-2A5] (IgG1) to Mouse IL-10
Mouse
IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human IL-10
Human
Western blot, ELISA, Functional Assay
Unconjugated

Details

Human IL-10
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (0.1 - 0.2 µg/ml)
  • ELISA (0.5 µg/ml)
  • Functional Assay (4 - 6 µg/ml)

Specificity and Use

IL-10 antibody was raised against recombinant Human IL-10.
Recognizes human IL-10 (Interleukin-10), an 18.5kD immunosuppressive cytokine originally known as cytokine synthesis inhibiting factor (CSIF), which specifically regulates immune-mediated inflammation and shares high sequence homology with murine IL-10 and the viral protein BCRF1. IL-10, produced by macrophages, mast cells, T cells, activated B cells and keratinocytes, inhibits the secretion of a variety of pro-inflammatory cytokines including TNFalpha, IL-1, IL-2, IL-3 and IL-8 and is chemotactic for CD8+ T cells. The suppressive ability of IL-10 has become a focus area for the treatment of Crohn's disease, but with conflicting results.
ELISA: This antibody may be used in an indirect ELISA or as the capture reagent in a sandwich ELISA.

Packaging

Lyophilized, PBS, pH 7.4.
100 µl Distilled Water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add azide.
For research use only.

About IL-10

P22301 NM_000572 NP_000563.1

IL10 Antibody, CSIF Antibody, GVHDS Antibody, IL-10 Antibody, IL10A Antibody, Interleukin-10 Antibody, Interleukin 10 Antibody, TGIF Antibody

IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.

Requested From: United States
Date Requested: 12/3/2016

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