Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone JES3-12G8] (IgG2a,k) to Human IL-10
Human (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [JES3-12G8]
Specificity and Use
IL-10 antibody was raised against cOS-expressed human IL-10
This antibody should be paired with purified JES3-9D7 antibody as the capture antibody in sandwhich ELISA, with purified recombinant human IL-10 as the standard. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.