Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MEM-238] (IgG1) to Human IGF2R / CD222
Human, Rhesus monkey
Human IGF2R / CD222
Human, Rhesus monkey (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MEM-238]
Protein G purified
Flow Cytometry (1:25 - 1:50)
Specificity and Use
IGF2R / CD222 antibody was raised against recombinant vaccinia virus containing CD222.
Recognizes human and mouse CD222. Recognizes an epitope located in the region between extracellular domains 2 and 5 (aa 192-697; UniProt Accession #P11717) of CD222 (Roberts, et al.). Species Cross-reactivity: Rhesus monkey
Flow Cytometry: 1:25-1: Flow Cytometry: Use 10 ul of the suggested working dilution to label 1E6 cells in 100ul.
PBS, pH 7.2, 0.1% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.