Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability,
bulk quotes, proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information requests about an LSBio product
or its application.
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution
agreements, or general business development.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Mouse Monoclonal [clone JBW902] (IgG2a) to Human IGF1R / IGF1 Receptor
Human, Mouse
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Mouse Monoclonal (IgG1) to Human IGF1R / IGF1 Receptor
Human
Immunoprecipitation, ELISA (applications tested for the base form of this product only)
FITC Conjugated
Details
Human IGF1R / IGF1 Receptor
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Fluorescein.
Also available conjugated with AP, APC, Biotin, HRP, PE.
Protein G purified
Unmodified
Applications
Immunoprecipitation
ELISA
(applications tested for the base form of this product only)
Specificity and Use
IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA. Epitope: aa283-440 (exon 4-6). Cellular Localization: Cell membrane.
Recognizes human Insulin-Like Growth Factor I Receptor, alpha (IGF1Ra) at 125kD. Does not significantly inhibit IGF-1 binding. Species cross-reactivity: Weakly reacts with rabbit. Does not react with rat. Porcine unknown.
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell.