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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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IGF1R / IGF1 Receptor Antibody (clone 1H7) IHC‑plus™ LS‑B2613
Note: This antibody replaces LS-C44711, LS-C57898, LS-C44711, LS-B3773
IGF1 Receptor antibody LS-B2613 is an unconjugated mouse monoclonal antibody to human IGF1 Receptor (IGF1R). Validated for Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B2613-50
50 µg (1 mg/ml)
Unavailable

Popular IGF1R / IGF1 Receptor Products

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Antibody
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Product Description

IGF1 Receptor antibody LS-B2613 is an unconjugated mouse monoclonal antibody to human IGF1 Receptor (IGF1R). Validated for Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
About IGF1R / IGF1 Receptor
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. P08069 NM_000875 NP_000866.1

IGF1R Antibody, CD221 antigen Antibody, CD221 Antibody, IGF1 Receptor Antibody, IGFR Antibody, IGF-I receptor Antibody, Soluble IGF1R variant 1 Antibody, Soluble IGF1R variant 2 Antibody, Type 1 IGF receptor Antibody, IGFIR Antibody, JTK13 Antibody


Specifications

Target
Human IGF1R / IGF1 Receptor
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [1H7]
Conjugations
Unconjugated. Also available conjugated with RPE.
Purification
Protein G purified
Modifications
Unmodified. Also available Low Endotoxin.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Western blot
  • Flow Cytometry (1:10)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Specificity
Recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221.
Usage
Immunohistochemistry: LS-B2613 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2613 was determined to be 10 ug/ml. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100ul. Histology Positive Control Tissue: Pancreas, placenta.
Presentation
PBS, pH 7.4, 0.09% sodium azide.
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 7/17/2018

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