Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Recognizes phosphorylated human IGF-1R, Mr ~95kD. Also corresponds to tyrosine 1185 in human insulin receptor preprotein, containing a 27 amino acid signal peptide. Cross-reacts with phosphorylated insulin and PDGF receptors which contain the I Y E motif. Slight cross-reactivity detected with EGFR in A431 cells expressing very high levels of EGFR. Species cross-reactivity: mouse. Broad species cross-reactivity predicted based on sequence homology. The immunizing sequence is conserved from Drosophila to mammals.
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell.