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Anti-IGF1R / IGF1 Receptor Antibody (aa1264-1367, clone JBW902) IHC-plus™ LS-B2905

Note: This antibody replaces LS-C7533
Catalog Size Price
LS-B2905-50 50 µg (1 mg/ml) Unavailable

Most Popular IGF1R / IGF1 Receptor Antibodies

Anti-IGF1R / IGF1 Receptor Antibody (C-Terminus) LS-C24709
Rabbit Polyclonal (IgG) to Human IGF1R / IGF1 Receptor
Human, Monkey, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
IHC of paraffin-embedded human prostate carcinoma using LS-C24709.
Anti-IGF1R / IGF1 Receptor Antibody (clone 3C8B1) LS-C82136
Mouse Monoclonal [clone 3C8B1] (IgG2b) to Human IGF1R / IGF1 Receptor
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
IHC of paraffin-embedded human stomach mucosae showing membrane location using IGF1R antibody with DAB staining.
Anti-IGF1R / IGF1 Receptor Antibody (clone 1H7) IHC-plus™ LS-B2613
Mouse Monoclonal [clone 1H7] (IgG1) to Human IGF1R / IGF1 Receptor
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2613 concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Anti-IGF1R / IGF1 Receptor Antibody (clone 24-31, Azide-free) LS-C88320
Mouse Monoclonal [clone 24-31] (IgG1) to Human IGF1R / IGF1 Receptor
Human, Rabbit
Immunoprecipitation, ELISA
Unconjugated, Azide-free
Anti-IGF1R / IGF1 Receptor Antibody (aa1264-1367, clone JBW902) IHC-plus™ LS-B2905
Mouse Monoclonal [clone JBW902] (IgG2a) to Human IGF1R / IGF1 Receptor
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Anti-IGF1 Receptor antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.

100% Guaranteed
Mouse Monoclonal [clone JBW902] (IgG2a) to Human IGF1R / IGF1 Receptor
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation (applications tested for the base form of this product only)
Unconjugated

Details

Human IGF1R / IGF1 Receptor
Mouse
Human, Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [JBW902]
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Protein A purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

GST fusion protein corresponding to residues 1264-1367 of human IGF-1 Receptor.
aa1264-1367
Recognizes human IGF-1 receptor beta chain, MW 95kD. Recognizes transmembrane domain. Not expected to cross-react with INSR based on sequence homology.
Immunohistochemistry: LS-B2905 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2905 was determined to be 5 ug/ml. Western Blot: 0.1-2 ug/ml. Detects the beta chain of IGF1R in RIPA lysates from C4 cells (mouse 3T3 cells that have been transfected with the human IGF1R) and in RIPA lysates from mouse 3T3/A31 cells. C4 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with LS-B2905. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Immunoprecipitation: 4 ug/ml immunoprecipitates IGF1R from 1 mg of RIPA lysates from C4 cells (mouse 3T3 cells that have been transfected with the human IGF1R) and in RIPA lysates from mouse 3T3/A31 cells.

Packaging

0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About IGF1R / IGF1 Receptor

P08069 NM_000875 NP_000866.1

IGF1R Antibody, CD221 antigen Antibody, CD221 Antibody, IGF1 Receptor Antibody, IGFR Antibody, IGF-I receptor Antibody, Soluble IGF1R variant 1 Antibody, Soluble IGF1R variant 2 Antibody, Type 1 IGF receptor Antibody, IGFIR Antibody, JTK13 Antibody

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell.

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.
Anti-IGF1 Receptor antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.

Immunohistochemistry

Anti-IGF1 Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.
Anti-IGF1 Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.

Requested From: 
Date Requested: 4/19/2018

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