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Anti-IGF1R / IGF1 Receptor Antibody (aa1264-1367, clone JBW902) IHC-plus™ LS-B2905

Note: This antibody replaces LS-C7533

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular IGF1R / IGF1 Receptor Antibodies

Anti-IGF1R / IGF1 Receptor Antibody (C-Terminus) LS-C24709
Rabbit Polyclonal (IgG) to Human IGF1R / IGF1 Receptor
Human, Monkey, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-IGF1R / IGF1 Receptor Antibody (clone 3C8B1) LS-C82136
Mouse Monoclonal [clone 3C8B1] (IgG2b) to Human IGF1R / IGF1 Receptor
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-IGF1R / IGF1 Receptor Antibody (clone 24-31, Azide-free) LS-C88320
Mouse Monoclonal [clone 24-31] (IgG1) to Human IGF1R / IGF1 Receptor
Human, Rabbit
Immunoprecipitation, ELISA
Unconjugated, Azide-free

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone JBW902] (IgG2a) to Human IGF1R / IGF1 Receptor
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Human IGF1R / IGF1 Receptor
Mouse
Human, Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [JBW902]
Unconjugated
Protein A purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot
  • Immunoprecipitation

Specificity and Use

IGF1R / IGF1 Receptor antibody was raised against gST fusion protein corresponding to residues 1264-1367 of human IGF-1 Receptor.
aa1264-1367
Recognizes human IGF-1 receptor beta chain, MW 95kD. Recognizes transmembrane domain. Not expected to cross-react with INSR based on sequence homology.
Immunohistochemistry: LS-B2905 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2905 was determined to be 5 ug/ml. Western Blot: 0.1-2 ug/ml. Detects the beta chain of IGF1R in RIPA lysates from C4 cells (mouse 3T3 cells that have been transfected with the human IGF1R) and in RIPA lysates from mouse 3T3/A31 cells. C4 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with LS-B2905. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Immunoprecipitation: 4 ug/ml immunoprecipitates IGF1R from 1 mg of RIPA lysates from C4 cells (mouse 3T3 cells that have been transfected with the human IGF1R) and in RIPA lysates from mouse 3T3/A31 cells.

Packaging

0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About IGF1R / IGF1 Receptor

P08069 NM_000875 NP_000866.1

IGF1R Antibody, CD221 antigen Antibody, CD221 Antibody, IGF1 Receptor Antibody, IGFR Antibody, IGF-I receptor Antibody, Soluble IGF1R variant 1 Antibody, Soluble IGF1R variant 2 Antibody, Type 1 IGF receptor Antibody, IGFIR Antibody, JTK13 Antibody

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell.

Immunohistochemistry

Immunohistochemistry
Anti-IGF1 Receptor antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.

Immunohistochemistry

Immunohistochemistry
Anti-IGF1 Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2905 concentration 5 ug/ml.

Requested From: United States
Date Requested: 12/4/2016

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