Target
Chicken IFNA1 / Interferon Alpha 1
Synonyms
IFNA1 | IFN | IFN-alpha 1b | IFNA@ | Interferon, alpha 1 | LeIF D | Interferon alpha 1b | Interferon alpha-1/13 | Interferon alpha-D | Interferon-alpha1 | IFL | IFN-ALPHA | IFN-alpha-1/13 | IFN-alphaD
Reactivity
Chicken
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant chicken Interferon alpha.
Specificity
Recognizes chicken Interferon alpha (chIFN-alpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. Does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.