Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP98] (IgG) to Human ICOS / CD278
IHC - Paraffin
Mouse Monoclonal [clone ANC6C6-A3] (IgG1,k) to Human ICOS / CD278
Flow Cytometry, ELISA, Functional Assay
Human ICOS / CD278
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [ANC6C6-A3]
Protein A purified
Specificity and Use
ICOS / CD278 antibody was raised against human HPB-MLT cells, recombinant human CD278(ICOS)-muIg.
Recombinant and cell surface CD278 (ICOS).
Flow Cytometry: 1:50 (or use 1.6?l of concentrated stock per 5 x 10^5 cell test), Function: Blocks binding of Recombinant CD275-muIg to CD278. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
50 mM sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5% Glycerol, 0.2% BSA, 0.04% sodium azide
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.