Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP98] (IgG) to Human ICOS / CD278
IHC - Paraffin
Mouse Monoclonal [clone ANC6C6-A3] (IgG1) to Human ICOS / CD278
Flow Cytometry, ELISA
Human ICOS / CD278
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [ANC6C6-A3]
Protein A purified
Specificity and Use
ICOS / CD278 antibody was raised against human HPB-MLT cells, recombinant human ICOS-muIg.
Binds to recombinant and cell surface ICOS.
Antibody blocks binding of Recombinant GL50-muIg to ICOS. Applications: Suitable for use in Flow Cytometry, ELISA. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.