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Anti-HTRA3 Antibody (aa250-300) IHC-plus™ LS-B2043

Note: This antibody replaces LS-C699
Catalog Size Price
LS-B2043-50 50 µg (0.5 mg/ml) Unavailable

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Anti-HTRA3 Antibody (aa250-300) IHC-plus™ LS-B2043
Rabbit Polyclonal (IgG) to Human HTRA3
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Immunohistochemistry Image
Anti-HTRA3 Antibody (aa112-144) LS-C98693
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Anti-HTRA3 Antibody (aa188-237) LS-C151754
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Anti-HTRA3 Antibody LS-C155475
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Anti-HTRA3 Antibody LS-C402923
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100% Guaranteed Publications (1)
Rabbit Polyclonal (IgG) to Human HTRA3
Human, Monkey, Rat
IHC - Paraffin, Western blot


Human HTRA3
Human, Monkey, Rat (tested or 100% immunogen sequence identity)
Bovine, Pig (at least 90% immunogen sequence identity)
IgG Polyclonal
Protein G purified


  • IHC - Paraffin (10 µg/ml)
  • Western blot (1 - 3 µg/ml)

Specificity and Use

HTRA3 antibody was raised against amino acids 273-287 (IVSTAQREGRELGLR)of human HtrA3 were used as immunogen. Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset (100%); Gorilla, Bovine, Pig, Pufferfish (93%); Mouse, Rat, Panda, Dog, Horse, Turkey, Chicken, Xenopus, Stickleback (87%); Hamster, Elephant, Opossum, Guinea pig, Platypus, Lizard, Salmon, Zebrafish (80%).
The amino acid sequence is 100% homologous in HtrA3, 80% homologous in HtrA1 and 71% homologous in HtrA2 and HtrA4.
Immunohistochemistry: LS-B2043 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2043 was determined to be 10 ug/ml.


PBS, 0.2% gelatin, 0.05% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

Publications (1)

The high-temperature requirement factor A3 (HtrA3) is associated with acquisition of the invasive phenotype in oral squamous cell carcinoma cells. Moriya Y, Uzawa N, Morita T, Mogushi K, Miyaguchi K, Takahashi K, Michikawa C, Sumino J, Tanaka H, Harada K. Oral oncology. Jan;51:84-9. [Full Text Article] [PubMed:25456008]

About HTRA3

P83110 NM_053044 NP_444272.1

HTRA3 Antibody, HtrA serine peptidase 3 Antibody, Serine protease HTRA3 Antibody, Tasp Antibody, Probable serine protease HTRA3 Antibody, PRSP Antibody

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans By similarity. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo.


Anti-HTRA3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2043 concentration 10 ug/ml.

Western blot

Western blot
Western blot of HtrA3 in rat heart lysate using antibody at 2 ug/ml.

Requested From: 
Date Requested: 2/18/2018

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