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HTR2A / 5-HT2A Receptor
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR2A, 5-HT2A, 5-HT-2A, 5-HT2a receptor, 5HT2A Receptor, 5-HT-2, 5-HT2A/2C, 5-HT2A/2C receptor, 5-HT2 receptor, HTR2, Serotonin 5-HT-2A receptor, Serotonin receptor 2A, Serotonin 2a receptor |
| Target Sequences: | NM_000621 NP_000612.1 P28223 |
Publications (4)
1
Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System. Fink LH, Anastasio NC, Fox RG, Rice KC, Moeller FG, Cunningham KA. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 40:1957-68. (WB; Rat)
[Full Text Article]
[PubMed:25666313]
[PMC:PMC4839520]
Related Antibodies: LS-C172270.
2
Human polyomavirus receptor distribution in brain parenchyma contrasts with receptor distribution in kidney and choroid plexus. Haley SA, O'Hara BA, Nelson CD, Brittingham FL, Henriksen KJ, Stopa EG, Atwood WJ. The American journal of pathology. 2015 August;185:2246-58. (Human)
[Full Text Article]
[PubMed:26056932]
[PMC:PMC4530127]
3
Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. Felsing DE, Anastasio NC, Miszkiel JM, Gilbertson SR, Allen JA, Cunningham KA. PloS one. 2018 August;13:e0203137. [Full Text Article]
[PubMed:30157263]
[PMC:PMC6114921]
Related Antibodies: LS-C172270.
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Fast Shipping
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Pig, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50 µg/$460
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa418-432) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa418-432) Antibody
Rabbit, Dog, Guinea pig, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$299
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa400-431) Antibody
Rabbit, Dog, Guinea pig, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa418-432) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (400-480 aa, C-terminal) Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa422-471) Antibody
Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTR2A / 5-HT2A Receptor Rabbit anti-Mouse Polyclonal (aa16-30) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
400 µl/$393
HTR2A / 5-HT2A Receptor Goat anti-Human Polyclonal (aa346-360) Antibody
Human, Monkey
Flo, Peptide-ELISA
Unconjugated
100 µg/$467
HTR2A / 5-HT2A Receptor Goat anti-Human Polyclonal (aa296-309) Antibody
Hamster, Human
IHC, Peptide-ELISA
Unconjugated
100 µg/$503
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (AP) Antibody
Mouse, Human
ELISA, WB
AP Conjugated
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (aa276-303) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$665
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HTR2A / 5-HT2A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Human, Chimpanzee, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$469
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