Human HTR2A / 5-HT2A Receptor

Rabbit

Human, Dog, Guinea pig, Rabbit (tested or 100% immunogen sequence identity)

Mouse, Rat, Bovine, Horse, Sheep (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the C-Terminus of human 5HT2A Receptor (AYKSSQLQMGQKKNS, aa418-432 of UniProt P28223). Percent identity by BLAST analysis: Human, Rabbit, Guinea pig, Dog (100%); Mouse, Rat, Ferret, Sheep, Cat, Bovine, Horse (93%); Pig (87%); Bat, Hamster, Elephant (80%).

aa418-432

Human HTR2A / 5-HT2A Receptor

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

The mammalian HTR2A (5-HT2A receptor) is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P28223 NCBI: NM_000621 NP_000612.1