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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HTR1B / 5‑HT1B Receptor Antibody (Internal) IHC‑plus™ LS‑A586 Best Seller
5-HT1B Receptor antibody LS-A586 is an unconjugated rabbit polyclonal antibody to 5-HT1B Receptor (HTR1B) from human and monkey. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A586-50
50 µg (1 mg/ml)
$425
In Stock for Immediate Shipment

Popular HTR1B / 5-HT1B Receptor Products

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Product Description

5-HT1B Receptor antibody LS-A586 is an unconjugated rabbit polyclonal antibody to 5-HT1B Receptor (HTR1B) from human and monkey. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About HTR1B / 5-HT1B Receptor
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. P28222 NM_000863 NP_000854.1

HTR1B Antibody, 5-HT-1B Antibody, 5-HT-1D-beta Antibody, 5-HT1B Antibody, 5-HT1b receptor Antibody, 5-HT1DB Antibody, 5HT1B Receptor Antibody, HTR1DB Antibody, Serotonin 5-HT-1b receptor Antibody, Serotonin receptor 1B Antibody, Serotonin 1b receptor Antibody, HTR1D2 Antibody, Serotonin 1D beta receptor Antibody


Specifications

Target
Human HTR1B / 5-HT1B Receptor
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Bat, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 17 amino acid peptide from internal region of human 5HT1B Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Bat, Horse, Pig (94%); Hamster, Panda, Bovine, Dog, Cat, Rabbit, Guinea pig (88%); Elephant, Opossum (82%).
Blocking Peptide
LS-E29104 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A586. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human 5HT1B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry: LS-A586 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A586 was determined to be 10 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: United States
Date Requested: 8/19/2018

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