Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Rat HTR1B / 5-HT1B Receptor
Rat, Human, Mouse
Rat HTR1B / 5-HT1B Receptor
Rat, Human, Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
HTR1B / 5-HT1B Receptor antibody was raised against this antibody was generated by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 8-26 and 263-278 of rat 5-HT1BR (Accession number P28564) (6).
A 40-41kD band is detected. Species cross-reactivity: Human, Mouse, Rat.
Suitable for use in Western Blot. Positive control: Human, mouse, or rat brain.
PBS, pH 7.2, 0.02% sodium azide
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.