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| Catalog Number | Size | Price |
|---|---|---|
| LS-B970-100 | 100 µl (0.5 mg/ml) | $485 |
PathPlus™ Polyclonal Rabbit anti‑Human HTR1A / 5‑HT1A Receptor Antibody (N‑Terminus, IHC, WB) LS‑B970
PathPlus™ Polyclonal Rabbit anti‑Human HTR1A / 5‑HT1A Receptor Antibody (N‑Terminus, IHC, WB) LS‑B970
Note: This antibody replaces LS-C30236
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Specifications
Description
HTR1A is the G-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a membrane receptor for various drugs and psychoactive substances, and plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain. It is involved in affecting neural activity, mood and behavior, as well as the response to anxiogenic stimuli. The receptor is expressed in various regions of the brain, in lymphoid tissues, and activated T cells.
References: J. Neurochem. 107 (2): 488–96, PMID: 18761712; Hum Brain Mapp. 2018 Feb;39(2):1043-1055, PMID: 29323797
Target
Human HTR1A / 5-HT1A Receptor
Synonyms
HTR1A | 5-HT-1A | 5HT1a | 5-HT1a receptor | 5HT1ar | 5HT1A receptor | 5-HT1A | ADRBRL1 | ADRB2RL1 | PFMCD | Serotonin 5-HT-1a receptor | Serotonin type 1a receptor | Serotonergic type 1A receptor | G-21 | Serotonin 1a receptor | Serotonin receptor 1A
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from N-Terminus of human HTR1A (P08908, NP_000515). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Chimpanzee (92%); Monkey (85%).
Epitope
N-Terminus
Specificity
Human HTR1A / 5-HT1A
Applications
- IHC
- IHC - Paraffin (2.5 µg/ml)
- Western blot (0.06 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B970 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B970 was determined to be 2.5 ug/ml.
Presentation
PBS, 0.09% sodium azide, 2% sucrose
Storage
Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About HTR1A / 5-HT1A Receptor
Validation
Anti-5HT1A Receptor antibody IHC of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-5HT1A Receptor antibody IHC of human brain, cortex, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ HTR1A / 5-HT1A Receptor Antibody (N-Terminus) for IHC, WB/Western LS-B970 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Expression of serotonin receptors in human hepatocellular cancer. Soll C, Riener MO, Oberkofler CE, Hellerbrand C, Wild PJ, DeOliveira ML, Clavien PA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Nov;18:5902-10.
Spatial cluster analysis of nanoscopically mapped serotonin receptors for classification of fixed brain tissue. Sams M, Silye R, Göhring J, Muresan L, Schilcher K, Jacak J. Journal of biomedical optics. 2014 19:11021. (IHC; Human)
Customer Reviews (0)
Featured Products
Species:
Rat, Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Rat, Human, Mouse
Applications:
IHC, Immunofluorescence, Western blot
Species:
Rat, Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, Western blot, ELISA
Species:
Mouse
Applications:
Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
