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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HSD11B1 / HSD11B Antibody (N‑Terminus) LS‑C24604
HSD11B antibody LS-C24604 is an unconjugated rabbit polyclonal antibody to HSD11B (HSD11B1) from mouse, rat and sheep. Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C24604-100
100 µg
$755

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Antibody (0.3 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Anti-HSD11B1 / HSD11B antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Product Description

HSD11B antibody LS-C24604 is an unconjugated rabbit polyclonal antibody to HSD11B (HSD11B1) from mouse, rat and sheep. Validated for ELISA and WB.
About HSD11B1 / HSD11B
HSD11B1 / HSD11B is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. P28845 NM_005525 NP_005516.1

HSD11B1 Antibody, 11-beta-HSD1 Antibody, 11-DH Antibody, CORTRD2 Antibody, HSD11B Antibody, HSD11L Antibody, SDR26C1 Antibody, HDL Antibody, HSD11 Antibody


Specifications

Target
Mouse HSD11B1 / HSD11B
Host
Rabbit
Reactivity
Mouse, Rat, Sheep (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 10 µg/ml)
  • ELISA (1:10000 - 1:100000)
Immunogen
A 16aa synthetic peptide mapping near the N-terminus of mouse 11b-HSD1 (KLH coupled). Peptide sequence homology: mouse and rat: 100%; sheep: 87%; human and chicken: 81%; porcine: 75%; rabbit: 68%.
Epitope
N-Terminus
Specificity
Recognizes mouse 11-beta Hydroxysteroid Dehydrogenase 1 (11b-HSD1). No significant sequence homology is seen with 11b-HSD2 or other proteins. See LS-C24601 for anti-11b-HSD Type II.
Usage
Suitable for use in ELISA and Western Blot. Western Blot: 1-10 ug/ml using ECL. ELISA: 1:10000-1:100000 using 50-100 ng control peptide/well.
Presentation
100 mM Tris, pH 7.5, 0.05% Sodium Azide, 40% Glycerol, 0.2% BSA
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/17/2018

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