HRS / HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

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Products

Antibodies (42)

Proteins (5)

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (42)

Recombinant (3)

Sandwich (2)

Target

HRS / HGS (51)

Reactivity

Human (46)

Mouse (31)

Rat (23)

Bat (1)

Bovine (3)

Dog (1)

Hamster (1)

Horse (1)

Monkey (1)

Pig (1)

Application

IHC (22)

IHC-P (8)

WB (40)

ELISA (21)

ICC (2)

IF (21)

IP (3)

Peptide-ELISA (7)

Host

rabbit (31)

mouse (10)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (23)

IgG1,k (6)

IgG2b (4)

Clonality

monoclonal mc (10)

polyclonal pc (32)

Clone

OTI1C2 (2)

OTI3H7 (2)

Format

96-Well Microplate (2)

96-Well Strip Plate (2)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (32)

Epitope

aa256-286 (7)

pTyr216 (3)

270-350 aa (2)

Internal (2)

pTyr334 (2)

Leu330 (1)

aa164-213 (1)

aa301-350 (1)

aa331-344 (1)

aa350-400 (1)

aa451-500 (1)

aa461-510 (1)

aa513-612 (1)

aa727-C-term (1)

p334 (1)

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Publications

No (51)

Sample Type

Adherent Cell Cultures (2)

Plasma (2)

Serum (2)

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Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ HRS / HGS Antibody (aa461-510) LS-B12780

(4.0) Rating

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa461-510) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ HRS / HGS Antibody (aa451-500) LS-B5664

(4.0) Rating

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa451-500) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$440

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HRS / HGS Antibody (phospho-Tyr334) LS-C199079

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (pTyr334) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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HRS / HGS Antibody (Internal) LS-C354125

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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HRS / HGS Antibody LS-C822432

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HRS / HGS Antibody LS-C800433

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

HRS / HGS Antibody LS-C416009

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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HRS / HGS Antibody (aa301-350) LS-C117954

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa301-350) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

HRS / HGS Antibody (270-350 aa) LS-C381523

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (270-350 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HRS / HGS Antibody (270-350 aa) LS-C384012

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (270-350 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HRS / HGS Antibody (p334) LS-C822648

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (p334) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HRS / HGS Antibody (Leu330) LS-C176533

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (Leu330) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

HRS / HGS Antibody LS-C666130

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

HRS / HGS Antibody LS-C658832

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$386

Select

HRS / HGS Antibody (aa513-612) LS-C308232

Antibody:

HRS / HGS Mouse anti-Human Monoclonal (aa513-612) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

HRS / HGS Antibody (Biotin) LS-C522376

Antibody:

HRS / HGS Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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HRS / HGS Antibody (FITC) LS-C532419

Antibody:

HRS / HGS Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

FITC Conjugated

Price:

100 µl/$904

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HRS / HGS Antibody (PE) LS-C650621

Antibody:

HRS / HGS Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

PE Conjugated

Price:

100 µl/$904

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HRS / HGS Antibody (APC) LS-C514160

Antibody:

HRS / HGS Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• Biotin
• FITC
• PE
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC

Select

HRS / HGS Antibody (aa256-286) LS-C327587

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa256-286) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

HRS / HGS Antibody (aa256-286, Biotin) LS-C278249

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa256-286) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

HRS / HGS Antibody (aa256-286, FITC) LS-C278251

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa256-286) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

HRS / HGS Antibody (aa256-286, PE) LS-C278250

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa256-286) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • PE

Select

HRS / HGS Antibody (phospho-Tyr334) LS-C822647

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (pTyr334) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HRS / HGS Antibody (aa256-286) LS-C99590

Antibody:

HRS / HGS Rabbit anti-Human Polyclonal (aa256-286) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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