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HRK / HARAKIRI
harakiri, BCL2 interacting protein (contains only BH3 domain)
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.
| Gene Name: | harakiri, BCL2 interacting protein (contains only BH3 domain) |
| Synonyms: | HRK, Activator of apoptosis Hrk, BID3, Death protein 5, DP5, HARAKIRI, Neuronal death protein DP5, BCL2-interacting protein |
| Target Sequences: | NM_003806 NP_003797.1 O00198 |
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