Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human HRH3 / Histamine 3 Receptor
Human HRH3 / Histamine 3 Receptor
Human, Monkey (tested or 100% immunogen sequence identity)
Western blot (1:1000 - 1:10000)
Specificity and Use
HRH3 / Histamine 3 Receptor antibody was raised against synthetic peptide corresponding to a region within amino acids 299 and 389 of Histamine H3 Receptor (SwissProt Q9Y5N1). Percent identity by BLAST analysis: Human, Monkey (100%).
Human Histamine 3 Receptor / HRH3
PBS, pH 7.0, 50% glycerol, 0.01% Thimerosal
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.