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HRH1 / Histamine H1 Receptor
histamine receptor H1
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
| Gene Name: | histamine receptor H1 |
| Family/Subfamily: | GPCR , Histamine |
| Synonyms: | HRH1, H1 histamine receptor, H1 receptor, Histamine 1 receptor, Histamine H1 receptor, H1-R, H1R, Histamine H(1) receptor, Histamine receptor H1, HisH1 |
| Target Sequences: | NM_000861 NP_000852.1 P35367 |
Publications (4)
1
A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, Sakamoto S, Ohuchi N, Kasahara M, Umezawa A, Akutsu H. JCI insight. 2017 2:e86492. (ICC; Human)
[Full Text Article]
[PubMed:28097227]
[PMC:PMC5214546]
Related Antibodies: LS-B1745.
2
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Hongzhong Li, Yi Xiao, Qin Li, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wen-Ling Kuo, Angela Halpin, Don L Gibbons, Hideo Yagita, Zhongming Zhao, Da Pang, Guosheng Ren, Cassian Yee, J Jack Lee, Dihua Yu. Cancer cell. 2022 January;40:36-52.e9. [Full Text Article]
[PubMed:34822775]
[PMC:PMC8779329]
Related Antibodies: LS-C331459.
3
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans. Jonathon L McClain, Elvio A Mazzotta, Nidia Maradiaga, Natalia Duque-Wilckens, Iveta Grants, Alfred J Robison, Fievos L Christofi, Adam J Moeser, Brian D Gulbransen. American journal of physiology. Gastrointestinal and liver physiology. 2020 December;319:G655-G668. [Full Text Article]
[PubMed:32996781]
[PMC:PMC7792668]
Related Antibodies: LS-B1745.
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HRH1 / Histamine H1 Receptor Goat anti-Human Polyclonal (aa471-484) Antibody
Bat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
Neuroscience
Fast Shipping
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa141-190) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HRH1 / Histamine H1 Receptor Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat
ELISA, WB
Unconjugated
50 µg/$872
HRH1 / Histamine H1 Receptor Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat
ELISA, WB
Unconjugated
100 µl/$801
HRH1 / Histamine H1 Receptor Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
100 µl/$904
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
HRH1 / Histamine H1 Receptor Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat
ELISA, WB
Unconjugated
100 µg/$832
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$321
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (aa273-301) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal (110-190 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HRH1 / Histamine H1 Receptor Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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