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HRAS / H-Ras

Harvey rat sarcoma viral oncogene homolog

HRAS / H-Ras belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Gene Name: Harvey rat sarcoma viral oncogene homolog
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: HRAS, C-H-RAS, C-has/bas p21 protein, C-ras-Ki-2 activated oncogene, C-HA-RAS1, CTLO, H-ras, H-RASIDX, GTP- and GDP-binding peptide B, GTPase HRas, H-Ras-1, HAMSV, HRAS1, K-RAS, Ha-Ras, Ha-Ras1 proto-oncoprotein, Transforming protein p21, N-ras, p21ras, RASH1, C-BAS/HAS, C-ha-ras, p19 H-RasIDX protein
Target Sequences: NM_005343 NP_005334.1 P01112

Publications (3)

1
Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Swarbrick A, Roy E, Allen T, Bishop JM. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5402-7. (WB) [PubMed:18378907] [PMC:PMC2291136]
2
DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Zhao T, Bao Y, Gan X, Wang J, Chen Q, Dai Z, Liu B, Wang A, Sun S, Yang F, Wang L. Theranostics. 2019 August;9:6175-6190. [Full Text Article] [PubMed:31534544] [PMC:PMC6735520] Related Antibodies: LS-C340614.
3
Single-cell in situ imaging of palmitoylation in fatty-acylated proteins. Xinxin Gao, Rami N Hannoush. Nature protocols. 2014 November;9:2607-23. [Full Text Article] [PubMed:25299157] Related Antibodies: LS-C165008.

☰ Filters
Antibodies (93)
Proteins (16)
ELISA Kits (6)
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Over-Expression Lysate (7)
Primary (93)
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HRAS / H-Ras (115)
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monoclonal mc (29)
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HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody.
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HRAS / H-Ras Mouse anti-Human Monoclonal (OTI1D9) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody.
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HRAS / H-Ras Mouse anti-Human Monoclonal (Carrier-free) (OTI1D9) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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HRAS / H-Ras Mouse anti-Human Monoclonal (OTI1C8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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HRAS / H-Ras Mouse anti-Human Monoclonal (Carrier-free) (OTI1C8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HRAS / H-Ras Antibody - Confocal immunofluorescence of HRAS Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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HRAS / H-Ras Rabbit anti-Human Polyclonal (aa146-176) Antibody
Mouse, Human
IF, WB
Unconjugated
400 µl/$393
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HRAS / H-Ras Rat anti-Human Monoclonal (aa62-76) Antibody
Mouse, Rat, Human
IF, IHC, IHC-Fr, IHC-P, IP, Neut, WB
Unconjugated
50 µg/$890
HRAS / H-Ras Antibody - Anti-HRAS / H-Ras antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
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HRAS / H-Ras Rabbit anti-Human Polyclonal (aa111-189) Antibody
Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HRAS / H-Ras Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HRAS / H-Ras Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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HRAS / H-Ras Mouse anti-Human Monoclonal (H-Ras-03) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$385
HRAS / H-Ras Antibody - Mouse Hras1 Antibody western blot of mouse bladder tissue lysates (35 ug/lane). The Mouse Hras1 antibody detected the Mouse Hras1 protein (arrow).
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HRAS / H-Ras Rabbit anti-Human Polyclonal (aa151-179) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
HRAS / H-Ras Antibody - Anti-HRAS mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HRAS.
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HRAS / H-Ras Mouse anti-Human Monoclonal (OTI1G8) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - Immunohistochemical analysis of H-Ras staining in human gastric cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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HRAS / H-Ras Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody.
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HRAS / H-Ras Mouse anti-Human Monoclonal (OTI1C2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-HRAS mouse monoclonal antibody.
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HRAS / H-Ras Mouse anti-Human Monoclonal (Carrier-free) (OTI1C2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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HRAS / H-Ras Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$351
HRAS / H-Ras Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-HRAS mouse monoclonal antibody.
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HRAS / H-Ras Mouse anti-Human Monoclonal (OTI2A1) Antibody
Mouse, Dog, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-HRAS mouse monoclonal antibody.
Select
HRAS / H-Ras Mouse anti-Human Monoclonal (Carrier-free) (OTI2A1) Antibody
Mouse, Dog, Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HRAS / H-Ras Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-HRAS mouse monoclonal antibody.
Select
HRAS / H-Ras Mouse anti-Human Monoclonal (OTI1A1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
HRAS / H-Ras Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-HRAS mouse monoclonal antibody.
Select
HRAS / H-Ras Mouse anti-Human Monoclonal (Carrier-free) (OTI1A1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HRAS / H-Ras Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with HRAS antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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HRAS / H-Ras Rabbit anti-Human Polyclonal (aa104-128) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
HRAS / H-Ras Rabbit anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$801
HRAS / H-Ras Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
24 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
HRAS / H-Ras Protein - 12.5% SDS-PAGE of human HRAS stained with Coomassie Blue
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Wheat Germ Extract
GST
46.42 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
18.7 kDa
20 µg/$150
HRAS / H-Ras Antibody - Immunohistochemistry of paraffin-embedded human spleen tissue using HRAS Antibody at dilution of 1:100
Select
HRAS / H-Ras Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 115 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).