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HP / Haptoglobin

haptoglobin

HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: haptoglobin
Synonyms: HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S
Target Sequences: NM_005143 NP_005134.1 P00738

Publications (7)

1
Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. White R, Atherly T, Guard B, Rossi G, Wang C, Mosher C, Webb C, Hill S, Ackermann M, Sciabarra P, Allenspach K, Suchodolski J, Jergens AE. Gut microbes. 2017 September;8:451-466. [Full Text Article] [PubMed:28678609] [PMC:PMC5628651] Related Antibodies: LS-C132998.
2
Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease. Atherly T, Rossi G, White R, Seo YJ, Wang C, Ackermann M, Breuer M, Allenspach K, Mochel JP, Jergens AE. PloS one. 2019 December;14:e0226780. [Full Text Article] [PubMed:31887117] [PMC:PMC6936794] Related Antibodies: LS-C132998.
3
Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Isabelle S Massart, Geneviève Paulissen, Audrey Loumaye, Pascale Lause, Sarah A Pötgens, Morgane M Thibaut, Estelle Balan, Louise Deldicque, Azeddine Atfi, Edouard Louis, Damien Gruson, Laure B Bindels, Marie-Alice Meuwis, Jean-Paul Thissen. Cancers. 2020 October;12: [Full Text Article] [PubMed:33142864] [PMC:PMC7693727] Related Antibodies: LS-C404051.
4
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
5
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
6
Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. Sun L, Pan J, Peng L, Fang L, Zhao X, Sun L, Yang Z, Ran Y. Annals of surgical oncology. 2012 Jul;19:2411-9. [Full Text Article] [PubMed:22219064] Related Antibodies: LS-B32.
7
The extracellular chaperone haptoglobin prevents serum fatty acid-promoted amyloid fibril formation of beta 2-microglobulin, resistance to lysosomal degradation, and cytotoxicity. Sultan A, Raman B, Rao ChM, Tangirala R. The Journal of biological chemistry. 2013 Nov;288:32326-42. [Full Text Article] [PubMed:24078632] [PMC:PMC3820869] Related Antibodies: LS-B32.
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HP / Haptoglobin Antibody - Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 31 ug/ml.
Select
Cancer
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$775
HP / Haptoglobin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IHC-P, IP, WB
Unconjugated
0.5 mg/$460
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HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$478; 100 µl/$914
HP / Haptoglobin Antibody - Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
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HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
1 mg/$622
HP / Haptoglobin Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using HP Polyclonal Antibody at dilution of 1:25.
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HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$561
HP / Haptoglobin Antibody - Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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HP / Haptoglobin Mouse anti-Human Monoclonal (26E11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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HP / Haptoglobin Rabbit anti-Human Polyclonal (aa296-322) (APC) Antibody
Human
FLISA, Flo, IF, IHC, WB
APC Conjugated
200 µl/$952
HP / Haptoglobin Antibody - HP / Haptoglobin antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HP / Haptoglobin Rabbit anti-Human Polyclonal (aa287-336) Antibody
Human
WB
Unconjugated
100 µl/$424
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HP / Haptoglobin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Antibody - Western blot of Haptoglobin antibody at 2 ug/ml with mouse stomach tissue secondary Goat polyclonal to rabbit at 1:10000 dilution predicted band size: 45 KDa observed band size: 45 KDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HP / Haptoglobin Rabbit anti-Human Polyclonal (aa19-406) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His
22.2 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His
19.8 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
HP / Haptoglobin Antibody - Anti-HP mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HP.
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HP / Haptoglobin Mouse anti-Human Monoclonal (OTI4C2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
HP / Haptoglobin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa295-322) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$440
Select
HP / Haptoglobin Sheep anti-Human Polyclonal Antibody
Human
ID, IF
Unconjugated
1 ml/$373
HP / Haptoglobin Antibody - HP antibody (0.01 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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HP / Haptoglobin Goat anti-Human Polyclonal (aa51-63) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
HP / Haptoglobin Antibody - Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Select
Cancer
HP / Haptoglobin Mouse anti-Human Monoclonal (aa19-406) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
HP / Haptoglobin Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HP.
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HP / Haptoglobin Mouse anti-Human Monoclonal (OTI2B11) Antibody
WB
Unconjugated
100 µl/$434
HP / Haptoglobin Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 272 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).