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HOXD13
homeobox D13
HOXD13 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly.
| Gene Name: | homeobox D13 |
| Synonyms: | HOXD13, Homeo box 4I, Homeobox D13, Homeobox protein Hox-4I, Homeobox protein Hox-D13, Homeo box D13, SPD, BDE, BDSD, HOX4I |
| Target Sequences: | NM_000523 NP_000514.2 P35453 |
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