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HOXB3 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).
Gene Name: | Homeobox B3 |
Synonyms: | HOXB3, Homeo box 2G, Homeobox protein Hox-2.7, Hox-2G, HOX2G, Homeo box B3, Hox-2.7, Homeobox protein Hox-2G, Homeobox B3, Homeobox protein Hox-B3, HOX2 |
Target Sequences: | NM_002146 NP_002137.4 |
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