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Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).
Gene Name: | hook microtubule-tethering protein 1 |
Synonyms: | HOOK1, H-hook1, HHK1, Hook homolog 1 (Drosophila), Protein Hook homolog 1 |
Target Sequences: | NM_015888 NP_056972.1 Q9UJC3 |
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