HNF4A / HNF4

hepatocyte nuclear factor 4, alpha

Hepatocyte nuclear factor 4 alpha (HNF4 alpha), a NR2 Hepatocyte NF4-Like receptor, is a liver-enriched transcription factor that is involved in the expression of liver-specific genes. HNF4 alpha controls the expression of transcription factor HNF1, which is important in the expression of hepatic genes, including those involved in glucose, cholesterol, and fatty acid metabolism. HNF4 alpha is essential for hepatocyte differentiation during liver development, metabolic regulation, and liver function. Although HNF4 alpha is a tissue-specific transcription factor, it is also an essential regulator of early embryonic events. Mutations in the HNF4 alpha gene are responsible for type-1 maturity-onset diabetes of the young (MODY1), which is characterized by a defect in insulin secretion. Mutations in HNF4 alpha binding sites have been linked to hemophilia B Leyden, atherosclerosis, hepatitis, and other diseases. HNF4 alpha has been linked to liver cancer via hepatitis and hepatitis B viral infections. Mouse embryos lacking HNF4 alpha fail to complete gastrulation due to dysfunction of the visceral endoderm. Recently, it has been shown that HNF4 alpha is critically involved in the PXR- and CAR-mediated transcriptional activation of CYP3A4, a gene involved in the metabolism of a wide range of drugs Tirona et al. 2003. At least four isoforms (HNF4 alpha1/HNF4B, HNF4 alpha2/HNF4A, HNF4 alpha3/HNF4C, and HNF4 alpha4) are produced by alternative splicing.

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Antibodies (80)

Proteins (16)

ELISA Kits (7)

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HNF4A / HNF4 (103)

Reactivity

Human (81)

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HNF4A / HNF4 Antibody (N-Terminus) LS-B969

(4.0) Rating

(1) Publication(s)

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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HNF4A / HNF4 Antibody (N-Terminus, Biotin) LS-C427087

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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HNF4A / HNF4 Antibody (N-Terminus, FITC) LS-C427088

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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IHC-plus™ HNF4A / HNF4 Antibody (aa2-15) LS-B3005

(4.0) Rating

Antibody:

HNF4A / HNF4 Goat anti-Human Polyclonal (aa2-15) Antibody

Reactivity:

Rabbit, Dog, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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HNF4A / HNF4 Antibody (phospho-Ser313) LS-C354006

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (pSer313) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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HNF4A / HNF4 Antibody LS-C758303

Antibody:

HNF4A / HNF4 Goat anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IF, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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HNF4A / HNF4 Antibody (aa281-312) LS-C97258

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (aa281-312) Antibody

Reactivity:

Rat, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F23712

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

39.06 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Rat HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F38651

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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HNF4A / HNF4 Antibody (C-Terminus) LS-B4568

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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HNF4A / HNF4 Antibody (phospho-Ser313) LS-C117375

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (pSer313) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Mouse HNF4A / HNF4 (Sandwich ELISA) ELISA Kit - LS-F35567

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

39.063 - 2500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Mouse/Human/Rat HNF4A / HNF4 (Cell-Based ELISA) ELISA Kit - LS-F2054

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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HNF4A / HNF4 Antibody (Internal) LS-C413423

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

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HNF4A / HNF4 Antibody (aa107-139) LS-C164947

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (aa107-139) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

400 µl/$393

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HNF4A / HNF4 Antibody (phospho-Ser313) LS-C801090

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (pSer313) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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HNF4A / HNF4 Antibody (clone 4E2) LS-C197427

Antibody:

HNF4A / HNF4 Mouse anti-Human Monoclonal (4E2) Antibody

Reactivity:

Human

Applications:

ELISA, IF, RNAi, WB

Format:

Unconjugated

Price:

50 µg/$423

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HNF4A / HNF4 Antibody (phospho-Ser313) LS-C825248

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (pSer313) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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HNF4A / HNF4 Antibody (250-330 aa) LS-C381547

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (250-330 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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HNF4A / HNF4 Antibody (Biotin) LS-C522411

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

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HNF4A / HNF4 Antibody LS-C331883

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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HNF4A / HNF4 Antibody (250-330 aa) LS-C383969

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal (250-330 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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HNF4A / HNF4 Antibody (aa1-315, clone OTI2H2) LS-C340017

Antibody:

HNF4A / HNF4 Mouse anti-Human Monoclonal (aa1-315) (OTI2H2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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HNF4A / HNF4 Antibody LS-C746987

Antibody:

HNF4A / HNF4 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

HNF4A / HNF4 Antibody LS-C808649

Antibody:

HNF4A / HNF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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