HNE / Neutrophil Elastase

elastase, neutrophil expressed

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

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Products

Antibodies (62)

ELISA Kits (31)

Proteins (9)

Type

Competitive EIA (4)

Custom (1)

Native (1)

Over-Expression Lysate (2)

Primary (62)

Recombinant (6)

Sandwich (23)

Sandwich CLIA (3)

Target

HNE / Neutrophil Elastase (102)

Reactivity

Human (59)

Mouse (25)

Rat (9)

Dog (1)

Guinea pig (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Application

IHC (3)

IHC-Fr (2)

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WB (38)

Flo (6)

EK (4)

ELISA (35)

ICC (9)

IE (3)

Inhb (4)

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Peptide-ELISA (1)

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rabbit (39)

mouse (19)

goat (1)

sheep (3)

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IHCPlus (1)

PathPlus Cancer (2)

PathPlus Cancer Pathology (2)

Isotype

IgG (23)

IgG1 (13)

IgG1,k (1)

IgG2a,k (2)

IgG2b (1)

IgM (2)

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monoclonal mc (21)

polyclonal pc (41)

Clone

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265-3K1 (1)

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6B6B10 (1)

6B6G6 (1)

ELA 10-101.5 (1)

ELA 10-103.2 (1)

ELA 11-207.2 (1)

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aa30-247 (8)

aa13-39 (7)

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Publications

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Yes (3)

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Cell Culture Supernatants (3)

Cell Lysates (2)

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Plasma (27)

Serum (28)

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Tag

6His, N-terminus (2)

GST (1)

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His-GST (1)

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Species

Human (8)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

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PathPlus™ HNE / Neutrophil Elastase Antibody LS-B4244

Cancer Pathology

Cancer

(5.0) Rating

(1) Publication(s)

Antibody:

HNE / Neutrophil Elastase Sheep anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IE, IHC-P

Format:

Unconjugated

Price:

50 µg/$565

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PathPlus™ HNE / Neutrophil Elastase Antibody LS-B14135

Cancer Pathology

Cancer

(5.0) Rating

Antibody:

HNE / Neutrophil Elastase Sheep anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC-P

Format:

Unconjugated

Price:

0.5 mg/$460

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HNE / Neutrophil Elastase Antibody LS-C781858

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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HNE / Neutrophil Elastase Antibody (HRP) LS-C23012

Antibody:

HNE / Neutrophil Elastase Sheep anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IE

Format:

HRP Conjugated

Price:

200 µg/$634

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HNE / Neutrophil Elastase Antibody (clone ELA10-101.5 (39A)) LS-C41872

Antibody:

HNE / Neutrophil Elastase Mouse anti-Human Monoclonal (ELA10-101.5 (39A)) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

0.2 mg/$471

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Monkey HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F43441

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Human HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F22767

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F20775

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Pig HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F36096

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Human HNE / Neutrophil Elastase Protein (Recombinant 6His, N-terminus) (aa30-267) - LS-G22905

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

27.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F11365

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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HNE / Neutrophil Elastase Antibody LS-C150762

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IE, WB

Format:

Unconjugated

Price:

1 ml/$477; 10 ml/$2,764

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HNE / Neutrophil Elastase Antibody (aa13-39, Biotin) LS-C264260

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Human Polyclonal (aa13-39) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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HNE / Neutrophil Elastase Antibody (aa13-39, FITC) LS-C264261

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Human Polyclonal (aa13-39) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

• Biotin
• FITC

• Biotin
• FITC

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Rat HNE / Neutrophil Elastase (CLIA) ELISA Kit - LS-F31099

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F4355

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.188 - 12 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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HNE / Neutrophil Elastase Antibody LS-C663862

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161

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HNE / Neutrophil Elastase Antibody (clone ELA 10-101.5) LS-C83032

Antibody:

HNE / Neutrophil Elastase Mouse anti-Human Monoclonal (ELA 10-101.5) Antibody

Reactivity:

Human

Applications:

EK, ELISA, Inhb

Format:

Unconjugated

Price:

100 µg/$372; 500 µg/$533

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HNE / Neutrophil Elastase Antibody LS-C488444

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

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HNE / Neutrophil Elastase Antibody (clone 1A11) LS-C139254

Antibody:

HNE / Neutrophil Elastase Mouse anti-Human Monoclonal (1A11) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$423

Select

HNE / Neutrophil Elastase Antibody (aa30-247) LS-B16906

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Human Polyclonal (aa30-247) Antibody

Reactivity:

Human

Applications:

ICC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Rat HNE / Neutrophil Elastase (Sandwich ELISA) ELISA Kit - LS-F4131

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$818

Select

HNE / Neutrophil Elastase Antibody LS-C662342

Antibody:

HNE / Neutrophil Elastase Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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HNE / Neutrophil Elastase Antibody LS-C128709

Antibody:

HNE / Neutrophil Elastase Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, RIA, WB

Format:

Unconjugated

Price:

20 µl/$473; 100 µl/$634

Select

HNE / Neutrophil Elastase Antibody (FITC) LS-C535648

Antibody:

HNE / Neutrophil Elastase Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

FITC Conjugated

Price:

100 µl/$951

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