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HMG1 / HMGB1
high mobility group box 1
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
| Gene Name: | high mobility group box 1 |
| Synonyms: | HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1 |
| Target Sequences: | NM_002128 NP_002119.1 P09429 |
Publications (23)
1
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Journal of virology. 2011 85:146-55. (WB; Human)
[PubMed:20980503]
[PMC:PMC3014182]
2
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. BMC cell biology. 2011 12:17. (ICC, IHC; Mouse)
[PubMed:21545732]
[PMC:PMC3224136]
3
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse)
[PubMed:21641551]
[PMC:PMC3293110]
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HMG1 / HMGB1
(220)
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(163)
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(80)
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(72)
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(15)
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(24)
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(17)
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(9)
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(28)
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(15)
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(15)
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(15)
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(20)
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(1)
Publications
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(211)
Yes
(9)
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(1)
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(15)
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(11)
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Low endotoxin level
(19)
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Biologically active
(4)
HMG1 / HMGB1 Mouse anti-Human Monoclonal (1D5) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Mouse anti-Human Monoclonal (IMG19N10B7) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$440
HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
HMG1 / HMGB1 Mouse anti-Human Monoclonal (1F3) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
HMG1 / HMGB1 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa25-75) Antibody
Chicken, Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µg/$386
HMG1 / HMGB1 Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal (aa1-215) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
E. coli
His, N-Terminal
26.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$968
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$768
E. coli
6His, C-terminus
Less than 1 EU/µg (determined by LAL method).
26.0 kDa
1 mg/$2,500; 50 µg/$355
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
Sandwich
96-Well Strip Plate
Mouse
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
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