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HM13 / IMP-1 / SPP
histocompatibility (minor) 13
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.
| Gene Name: | histocompatibility (minor) 13 |
| Family/Subfamily: | Protease , Aspartic A22B |
| Synonyms: | HM13, DJ324O17.1, HIMP1, IMP1, Intramembrane protease 1, H13, MSTP086, IMP-1, IMPAS, IMPAS-1, Presenilin-like protein 3, PSL3, Signal peptide peptidase, Signal peptide peptidase beta, SPP, PSENL3, SPPL1 |
| Target Sequences: | NM_030789 NP_110416.1 Q8TCT9 |
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