Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein A purified
Specificity and Use
HLA-E antibody was raised against recombinant HLA-E.
Reacts with the denatured heavy chain of the non-classical MHC class I HLA-E molecule. Does not detect native HLA-E by flow cytometry and does not cross-react with HLA-A, -B, -C or G.
Suitable for use in Western Blot. Not suitable for Flow Cytometry. Western Blot: Detects a band of approximately 43kD. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
HLA-E Antibody, EA2.1 Antibody, HLAE Antibody, MHC HLA-E alpha-2.1 Antibody, MHC HLA-E alpha-1 Antibody, EA1.2 Antibody, HLA-6.2 Antibody, MHC class I antigen E Antibody, QA1 Antibody
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons.