Human HLA-DR1

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

MEM-267

Unconjugated

Purified

Concentrated

Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.

HLA-DR1 belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kD. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. The antibody MEM-267 specifically binds to the empty but not peptide-loaded form of HLADR1.

• Western blot
• Flow Cytometry
• ELISA

PBS, pH 7.4, 15 mM Sodium Azide

Store at 2-8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.