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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HLA‑DR Antibody LS‑C24534
HLA-DR antibody LS-C24534 is an unconjugated rat monoclonal antibody to human HLA-DR. Validated for Flow and IHC.
Antibody
Catalog
Size
Price
LS-C24534-250
250 µg (1 mg/ml)
Unavailable

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Product Description

HLA-DR antibody LS-C24534 is an unconjugated rat monoclonal antibody to human HLA-DR. Validated for Flow and IHC.
About HLA-DR
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in HLA-mismatched donors.

Specifications

Target
Human HLA-DR
Host
Rat
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, Biotin, FITC, HRP, PE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
HLA-DR antibody was raised against eHR-B Ramos cells.
Specificity
Recognizes a monomorphic determinant of human HLA-DR, expressed by B lymphocytes, monocytes and activated T cells. This clone has also been shown to recognize a polymorphic determinant in mice, mapping to the H-2 I-A region. * This clone has been described reacting with paraffin embedded material following PLP (periodate-lysine-paraformaldehyde) fixation-refer to ref. Whiteland et al.-see reference 3.
Usage
Flow Cytometry. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1E6 cells in 100ul. Applications: Flow Cytometry. Immunohistochemistry: Frozen, Paraffin.
Presentation
PBS, pH 7.4, 0.09% sodium azide.
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/17/2018

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