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HLA-DPB1

major histocompatibility complex, class II, DP beta 1

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Gene Name: major histocompatibility complex, class II, DP beta 1
Synonyms: HLA-DPB1, Class II HLA beta chain, HLA-DP1B, MHC class II antigen DPbeta1, MHC class II antigen DPB1, MHC class II HLA-DRB1, MHC HLA DPB1, HLA-DPB, MHC class II HLA-DP-beta-1, DPB1, HLA DP14-beta chain, MHC class II HLA-DP-beta
Target Sequences: NM_002121 NP_002112.3 P04440

Publications (1)

1
Lymphocyte predominant cells of nodular lymphocyte predominant Hodgkin lymphoma interact with rosetting T cells in an immunological synapse. Julia Bein, Lorenz Thurner, Martin-Leo Hansmann, Sylvia Hartmann. American journal of hematology. 2020 December;95:1495-1502. [Full Text Article] [PubMed:32815561]

☰ Filters
Antibodies (35)
Proteins (5)
Over-Expression Lysate (2)
Primary (35)
Recombinant (3)
HLA-DPB1 (40)
Human (35)
Mouse (9)
Rat (7)
Dog (3)
Gibbon (3)
Rabbit (3)
IHC (28)
IHC-P (11)
WB (27)
Flo (4)
ELISA (14)
IF (4)
IP (1)
Peptide-ELISA (1)
rabbit (29)
mouse (6)
Product Group
IHCPlus (2)
IgG (22)
IgG2a,k (1)
IgG2b,k (4)
monoclonal mc (5)
polyclonal pc (30)
6C6 (1)
BraFB6 (2)
SPM421 (2)
APC Conjugated (1)
Azide-free (3)
Biotin Conjugated (3)
BSA-free (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (24)
aa77-105 (7)
aa98-147 (4)
No (40)
6His, N-terminus (1)
GST (2)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
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HLA-DPB1 Mouse anti-Human Monoclonal (BraFB6) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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HLA-DPB1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (BraFB6) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
HLA-DPB1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HLA-DPB1 Mouse anti-Human Monoclonal (6C6) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
HLA-DPB1 Antibody - Immunohistochemical analysis of HLA-DPB1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
HLA-DPB1 Antibody - Western blot analysis of extracts of various cell lines, using HLA-DPB1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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HLA-DPB1 Mouse anti-Human Monoclonal (SPM421) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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HLA-DPB1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM421) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
HLA-DPB1 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HLA-DPB1 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DPB1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
HLA-DPB1 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DPB1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
HLA-DPB1 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DPB1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
HLA-DPB1 Protein
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E. coli
6His, N-terminus
26.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
HLA-DPB1 Antibody - Immunohistochemistry of paraffin-embedded human lymphonodus using HLA-DPB1 antibodyat dilution of 1:100 (40x lens).
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HLA-DPB1 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer tissue  using HLA-DPB1 Polyclonal Antibody at dilution of 1:50(×200)
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HLA-DPB1 Antibody - HLA-DPB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human tonsil tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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HLA-DPB1 Rabbit anti-Human Polyclonal (aa77-105) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
HLA-DPB1 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$351
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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HLA-DPB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).