(tested or 100% immunogen sequence identity)
Protein G purified
- IHC - Paraffin (10 µg/ml)
- IHC - Frozen
- Flow Cytometry (10 µg/ml)
- Functional Assay (5 - 10 µg/ml)
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HLA-A2 antibody was raised against papain solubilized HLA-A2.
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. The HLA A gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene. The antibody recognizes the human HLA A2 histocompatability antigen. The epitope recognized by this has been studied extensively and would appear to include the carboxy-terminus of the alpha-2 helix and a turn on one of the underlying beta strands. The antibody may be used for the flow cytometric detection of HLA A2 expression and has also been used for immunoaffinity purification of HLA A2 molecules. Functionally this is reported to inhibit MHC restricted cellular cytotoxicity. The antibody recognizes A2 and A28 others not tested.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Store at -20°C. Avoid freeze-thaw cycles.
For research use only.
This antibody carries the LSBio 100% Guarantee.