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HLA-A/B/C

MHC Class I HLA-A / HLA-B / HLA-C

The human leukocyte antigen (HLA) system is the locus of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and has many other functions. The HLA genes are the human versions of the major histocompatibility complex (MHC) genes that are found in most vertebrates (and thus are the most studied of the MHC genes). The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. The major HLAs are essential elements for immune function. Different classes have different functions: HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these particular peptides are small polymers, about 9 amino acids in length. Foreign antigens presented by MHC class I attract killer T-cells (also called CD8 positive- or cytotoxic T-cells) that destroy cells.

HLA-A/B/C Target Details

Target Name: MHC Class I HLA-A / HLA-B / HLA-C

Publications (5)

1
Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via Vgamma9gammadelta T cell activation. Takahara M, Miyai M, Tomiyama M, Mutou M, Nicol AJ, Nieda M. Journal of leukocyte biology. 2008 83:742-54. [PubMed:18156189] Related Antibodies: LS-C41097.
2
IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO. Journal of immunology (Baltimore, Md. : 1950). 2008 181:1323-32. [PubMed:18606687] Related Antibodies: LS-C41097.
3
Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. Lnemann A, Lnemann JD, Roberts S, Messmer B, Barreira da Silva R, Raine CS, Mnz C. Journal of immunology (Baltimore, Md. : 1950). 2008 181:6170-7. [PubMed:18941207] [PMC:PMC2596922] Related Antibodies: LS-C41097.
4
Glutaraldehyde treatment of allograft tissue decreases allosensitization after the Norwood procedure. Laing BJ, Ross DB, Meyer SR, Campbell P, Halpin AM, West LJ, Rebeyka IM. The Journal of thoracic and cardiovascular surgery. 2010 139:1402-8. [PubMed:20236668] Related Antibodies: LS-C41097.
5
IFN-? enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. Shuai Shao, Lam C Tsoi, Mrinal K Sarkar, Xianying Xing, Ke Xue, Ranjitha Uppala, Celine C Berthier, Chang Zeng, Matthew Patrick, Allison C Billi, Joseph Fullmer, Maria A Beamer, Bethany Perez-White, Spiro Getsios, Andrew Schuler, John J Voorhees, Sung Choi, Paul Harms, J Michelle Kahlenberg, Johann E Gudjonsson. Science translational medicine. 2019 September;11: [Full Text Article] [PubMed:31554739] [PMC:PMC7285657] Related Antibodies: LS-C190912.
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☰ Filters
Antibodies (65)
Primary (65)
HLA-A/B/C (65)
Human (61)
Mouse (4)
Rat (2)
Baboon (4)
Bovine (15)
Cat (6)
Cynomolgus (3)
Cynomolgus monkey (1)
Feline (5)
Macaque (2)
Monkey (4)
Non-Human Primates (7)
Primate (4)
Rabbit (1)
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Shrew (2)
IHC (16)
IHC-Fr (15)
WB (21)
Flo (57)
Block (1)
Ctox (1)
ELISA (12)
Func (6)
ICC (6)
IF (10)
Inhb (1)
IP (26)
Peptide-ELISA (1)
rabbit (4)
mouse (55)
rat (6)
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IHCPlus (2)
IgG (2)
IgG1 (6)
IgG1,k (1)
IgG2a (25)
IgG2a,k (18)
IgG2b (6)
IgG3 (5)
monoclonal mc (61)
polyclonal pc (4)
246-B8.E7 (2)
Bu8 (1)
MEM-123 (5)
MEM-147 (4)
W6/32 (30)
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YTH862 (2)
YTH862.2 (1)
AF488 Conjugated (1)
AF647 Conjugated (1)
APC Conjugated (1)
Azide-free (3)
Biotin Conjugated (7)
BSA-free (1)
Cy5 Conjugated (1)
Cy5.5 (1)
Cy5.5 Conjugated (1)
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FITC Conjugated (8)
HRP Conjugated (3)
Low Endotoxin (4)
PE (3)
PE Conjugated (8)
PerCP Conjugated (3)
RPE Conjugated (1)
Unconjugated (29)
Internal (1)
aa204-253 (1)
No (63)
Yes (2)
Select
HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Bovine, Cat, Cynomolgus, Cynomolgus monkey, Rhesus monkey, Human, Monkey, Baboon
Block, Flo, IF, IHC, Inhb, IP, WB
Unconjugated
100 µg/$449
HLA-A/B/C Antibody - HEK293 cells were transfected with RelA or empty vector and 24hrs later cell extracts harvested using a 1% CHAPS lysis buffer. Extracts were resolved by non-denaturing, non-reducing electrophoresis, transferred to nitrocellulose, and probed with a 1:500 d
Select
HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Bovine, Cat, Human, Monkey, Baboon
Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$268
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Low Endotoxin) (W6/32) Antibody
Bovine, Feline, Non-Human Primates, Human
ELISA, Flo, Func, ICC, IHC, IHC-Fr, IP, WB
Unconjugated, Low Endotoxin
0.1 mg/$330
HLA-A/B/C Antibody - Surface staining of human peripheral blood cells with anti-HLA-class I (W6/32) PE
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HLA-A/B/C Mouse anti-Human Monoclonal (PE) (W6/32) Antibody
Bovine, Feline, Non-Human Primates, Human
ELISA, Flo, Func, ICC, IHC-Fr, IP, WB
PE Conjugated
0.1 mg/$435
Select
HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Human
Ctox, Flo
Unconjugated
500 µg/$442
HLA-A/B/C Antibody - Staining of peripheral blood lymphocytes with anti-HLA-ABC: Low Endotoxin. This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Low Endotoxin) (W6/32) Antibody
Human
ELISA, Flo, IF, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.5 mg/$671
HLA-A/B/C Antibody - Western blot of human Ramos B cell line lysate (1% laurylmaltoside); non-reduced sample, immunostained by mAb MEM-147  and goat anti-mouse IgG (H+L)-HRP conjugate.
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HLA-A/B/C Mouse anti-Human Monoclonal (MEM-147) Antibody
Human
Flo, IP, WB
Unconjugated
0.1 mg/$309
Select
HLA-A/B/C Mouse anti-Human Monoclonal (PE) (MEM-147) Antibody
Human
Flo, IP, WB
PE Conjugated
0.1 mg/$393
Select
HLA-A/B/C Mouse anti-Human Monoclonal (FITC) (W6/32 HLK) Antibody
Human
Flo
FITC Conjugated
100 µg/$357
HLA-A/B/C Antibody - IHC with HLA-A/B/C antibody on frozen human tonsil.
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HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
50 µg/$460
Select
HLA-A/B/C Rat anti-Human Monoclonal (YTH862) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
200 µg/$732
HLA-A/B/C Antibody - IHC with HLA-A/B/C antibody on frozen human tonsil.
Select
HLA-A/B/C Mouse anti-Human Monoclonal (MEM-123) Antibody
Bovine, Human, Non-Human Primates
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
0.05 mg/$460
HLA-A/B/C Antibody - Surface staining of K562 cells with anti-HLA-class I (MEM-123) PE.
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HLA-A/B/C Mouse anti-Human Monoclonal (PE) (MEM-123) Antibody
Bovine, Human, Non-Human Primates
ELISA, Flo, IP
PE Conjugated
0.1 mg/$393
HLA-A/B/C Antibody - Western blot analysis of lysates from Ramos cells, using HLA Class I antibody.
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HLA-A/B/C Rabbit anti-Human Polyclonal (aa204-253) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Azide-free) (W6/32 HLK) Antibody
Human
WB
Unconjugated, Azide-free
1 mg/$634
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Biotin) (W6/32 HLK) Antibody
Human
Flo
Biotin Conjugated
100 µg/$339
Select
HLA-A/B/C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$351
Select
HLA-A/B/C Mouse anti-Human Monoclonal (HRP) (W6/32) Antibody
Human
IHC-Fr
HRP Conjugated
0.1 mg/$432
HLA-A/B/C Antibody - Staining of human peripheral blood monocytes with MOUSE ANTI HUMAN HLA ABC: BIOTIN. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-A/B/C Mouse anti-Human Monoclonal (Biotin) (W6/32) Antibody
Human
Flo
Biotin Conjugated
100 µg/$416
Select
HLA-A/B/C Mouse anti-Human Monoclonal (FITC) (Bu8) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
HLA-A/B/C Antibody - Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN HLA ABC: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
HLA-A/B/C Mouse anti-Human Monoclonal (FITC) (W6/32) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$432
HLA-A/B/C Antibody - Surface staining (mass cytometry) of PBMC after Ficoll-Paque separation with anti-HLA-class I (W6/32) Gd155. Gated on DNA.
Select
HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Bovine, Feline, Non-Human Primates, Human
ELISA, Flo, Func, ICC, IHC-Fr, IP, WB
Unconjugated
0.1 mg/$330
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Low Endotoxin) Antibody
Bovine, Cat, Shrew, Cynomolgus, Macaque, Human, Monkey, Baboon
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated, Low Endotoxin
500 µg/$968
Select
HLA-A/B/C Mouse anti-Human Monoclonal (W6/32) Antibody
Human
Flo, IHC, IP, WB
Unconjugated
25 µg/$224; 100 µg/$251
Select
HLA-A/B/C Mouse anti-Human Monoclonal (Azide-free, Low Endotoxin) (W6/32) Antibody
Human
Flo, IHC, IP, WB
Unconjugated, Azide-free, Low Endotoxin
50 µg/$248; 500 µg/$333; 1 mg/$433
Viewing 1-25 of 65 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).