Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HK1 Antibody, Brain form hexokinase Antibody, Hexokinase 1 Antibody, Hexokinase type I Antibody, HK I Antibody, HK1-tb Antibody, HK1-tc Antibody, HKI Antibody, Hexokinase type 1 Antibody, HK1-ta Antibody, HXK1 Antibody, Glycolytic enzyme Antibody, Hexokinase-1 Antibody, Type 1 hexokinase Antibody, Type i hexokinase Antibody
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
HK1 Antibody (L93) western blot of MCF-7 cell line lysates (35 ug/lane). The HK1 antibody detected the HK1 protein (arrow).
The anti-HK1 antibody is used in Western blot to detect HK1 in mouse skeletal muscle tissue lysate.
Western blot of HK1 (arrow) using HK1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HK1 gene (Lane 2) (Origene Technologies).