HIV-1 Reverse Transcriptase

HIV-1 rev / Reverse Transcriptase

Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs. Rev itself is translated from a fully spliced mRNA that readily exits the nucleus. Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1. KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus. In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs. Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface. Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex. Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export. Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import. The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm By similarity. Interacts with DDX1; the interaction is necessary for proper subcellular localization of this protein.

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Products

Antibodies (14)

Type

Primary (14)

Target

HIV-1 Reverse Transcriptase (14)

Reactivity

Human Immunodeficiency Virus (14)

Application

WB (12)

ELISA (10)

RIA (1)

Host

rabbit (4)

mouse (9)

sheep (1)

Product Group

Retroviridae (14)

Isotype

IgG (3)

IgG1 (6)

Clonality

monoclonal mc (9)

polyclonal pc (5)

Clone

8C4D7 (2)

AS34 (1)

AS35 (1)

RMAb6 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (3)

HRP Conjugated (1)

Unconjugated (8)

Publications

No (14)

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HIV-1 Reverse Transcriptase Antibody (clone RMAb6) LS-C84230

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (RMAb6) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$500

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HIV-1 Reverse Transcriptase Antibody LS-C84121

Antibody:

HIV-1 Reverse Transcriptase Rabbit anti-Human Immunodeficiency Virus Polyclonal Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$429

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HIV-1 Reverse Transcriptase Antibody LS-C84120

Antibody:

HIV-1 Reverse Transcriptase Rabbit anti-Human Immunodeficiency Virus Polyclonal Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

500 µl/$473

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HIV-1 Reverse Transcriptase Antibody (HRP) LS-C68034

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (HRP) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

200 Tests/$675

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HIV-1 Reverse Transcriptase Antibody LS-C68033

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$655

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HIV-1 Reverse Transcriptase Antibody (clone 8C4D7) LS-C84232

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (8C4D7) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$398

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HIV-1 Reverse Transcriptase Antibody LS-C84122

Antibody:

HIV-1 Reverse Transcriptase Rabbit anti-Human Immunodeficiency Virus Polyclonal Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$300

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HIV-1 Reverse Transcriptase Antibody (Biotin) LS-C68035

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (Biotin) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$778

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HIV-1 Reverse Transcriptase Antibody (clone 8C4D7, FITC) LS-C86724

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (FITC) (8C4D7) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$318

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HIV-1 Reverse Transcriptase Antibody (FITC) LS-C84195

Antibody:

HIV-1 Reverse Transcriptase Rabbit anti-Human Immunodeficiency Virus Polyclonal (FITC) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$460

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HIV-1 Reverse Transcriptase Antibody (clone AS34) LS-C140449

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (AS34) Antibody

Reactivity:

Human Immunodeficiency Virus

Format:

Unconjugated

Price:

100 µg/$455

Select

HIV-1 Reverse Transcriptase Antibody (FITC) LS-C68036

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (FITC) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

WB

Format:

FITC Conjugated

Price:

50 Tests/$648

Select

HIV-1 Reverse Transcriptase Antibody LS-C85852

Antibody:

HIV-1 Reverse Transcriptase Sheep anti-Human Immunodeficiency Virus Polyclonal Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$386

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HIV-1 Reverse Transcriptase Antibody (clone AS35, Biotin) LS-C140452

Antibody:

HIV-1 Reverse Transcriptase Mouse anti-Human Immunodeficiency Virus Monoclonal (Biotin) (AS35) Antibody

Reactivity:

Human Immunodeficiency Virus

Applications:

RIA

Format:

Biotin Conjugated

Price:

100 µg/$455

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