Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2D2] (IgG1) to Human HIF3A / HIF3-Alpha
IHC, IHC - Paraffin, Western blot
Rabbit Polyclonal to Human HIF3A / HIF3-Alpha
Human HIF3A / HIF3-Alpha
Human, Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
Bacterially expressed human HIF-3 alpha (N-terminus).
Recognizes mouse HIF-3 alpha.
Suitable for use in Western Blot.
Tris-citrate/phosphate buffer, pH 7-8
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C.
HIF3A Antibody, BHLHe17 Antibody, HIF-3A Antibody, IPAS Antibody, HIF3-alpha-1 Antibody, Inhibitory PAS domain protein Antibody, PASD7 Antibody, HIF-3-alpha Antibody, HIF3-alpha Antibody, Member of PAS protein 7 Antibody, MOP7 Antibody
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription.