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HIF3A / HIF3-Alpha
hypoxia inducible factor 3, alpha subunit
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea.
| Gene Name: | hypoxia inducible factor 3, alpha subunit |
| Synonyms: | HIF3A, BHLHe17, HIF-3A, IPAS, HIF3-alpha-1, Inhibitory PAS domain protein, PASD7, HIF-3-alpha, HIF3-alpha, Member of PAS protein 7, MOP7 |
| Target Sequences: | NM_152795 NP_690008.2 Q9Y2N7 |
Publications (3)
1
Gene induction during differentiation of human pulmonary type II cells in vitro. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. American journal of respiratory cell and molecular biology. 2006 34:727-37.
[PubMed:16474099]
[PMC:PMC2644235]
2
Hypoxia-inducible factor expression in human RPE cells. Forooghian F, Razavi R, Timms L. The British journal of ophthalmology. 2007 91:1406-10.
[PubMed:17567660]
[PMC:PMC2001032]
3
Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Jackson IL, Zhang X, Hadley C, Rabbani ZN, Zhang Y, Marks S, Vujaskovic Z. Free radical biology & medicine. 2012 53:337-46. (WB; Mouse)
[PubMed:22588005]
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HIF3A / HIF3-Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (aa305-354) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (OTI4C2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (aa355-669) (Carrier-free) (OTI4C2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (aa355-669) (OTI2D2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (aa355-669) (Carrier-free) (OTI2D2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
100 µl/$567
HIF3A / HIF3-Alpha Goat anti-Human Polyclonal (aa4-17) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µg/$503
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HIF3A / HIF3-Alpha Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HIF3A / HIF3-Alpha Rabbit anti-Mouse Polyclonal (aa581-592) Antibody
Mouse
ELISA
Unconjugated
100 µg/$973
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (OTI2F7) Antibody
Human
WB
Unconjugated
100 µl/$434
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (aa355-669) (Carrier-free) (OTI2F7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (OTI5B7) Antibody
Human
WB
Unconjugated
100 µl/$434
HIF3A / HIF3-Alpha Mouse anti-Human Monoclonal (aa355-669) (Carrier-free) (OTI5B7) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
HIF3A / HIF3-Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$567
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