Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IHC - Paraffin, IHC - Frozen
Specificity and Use
HIF1A / HIF1 Alpha antibody was raised against human HIF-1 alpha amino acids 329-530.
Specific for HIF-1 alpha. Species cross-reactivity: Human and rat. Mouse fibroblasts can be used for Western blot only.
Suitable for use in Immunohistochemistry. Recommended Immunohistochemistry: 1:1000 to 1:8000 (paraffin-embedded or frozen sections). Cellular Localization: Nucleus. Positive control: MCF7 human nuclear extracts.
Supplied as a liquid in Tris-Glycine, 0.15M sodium chloride, 0.05% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
HIF1A Antibody, ARNT-interacting protein Antibody, ARNT interacting protein Antibody, BHLHe78 Antibody, HIF1 Alpha Antibody, Hypoxia-inducible factor1alpha Antibody, HIF-1A Antibody, HIF1 Antibody, MOP1 Antibody, Member of PAS superfamily 1 Antibody, PASD8 Antibody, HIF-1-alpha Antibody, HIF-1alpha Antibody, HIF1-ALPHA Antibody, Member of PAS protein 1 Antibody
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.