HDAC3

histone deacetylase 3

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

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Products

Antibodies (79)

Proteins (8)

ELISA Kits (5)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (2)

Primary (79)

Recombinant (6)

Sandwich (3)

Target

HDAC3 (92)

Reactivity

Human (81)

Mouse (44)

Rat (37)

Bat (4)

Bovine (4)

Chicken (6)

Chimpanzee (3)

Dog (6)

Gibbon (3)

Guinea pig (4)

Horse (4)

Monkey (5)

Non-Human Primate (1)

Orangutan (3)

Pig (7)

Rabbit (6)

Sheep (1)

Xenopus (4)

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Application

IHC (41)

IHC-P (18)

WB (77)

ChIP-Seq (2)

ChrIP (7)

ELISA (31)

ICC (10)

IF (29)

IP (7)

Peptide-ELISA (5)

Host

rabbit (58)

mouse (20)

goat (1)

Product Group

IHCPlus (3)

Isotype

IgG (40)

IgG1 (4)

IgG2a (6)

IgG2a,k (6)

Clonality

monoclonal mc (20)

polyclonal pc (59)

Clone

3A7B5 (2)

3G6 (1)

7G6C5 (2)

OTI4E10 (2)

Format

96-Well Microplate (2)

96-Well Strip Plate (3)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (6)

Carrier-free (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (55)

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Epitope

C-Terminus (11)

aa383-412 (7)

pSer424 (5)

aa1-428 (4)

370-450 aa (2)

Amino Acid: 224-428 (2)

aa1-235 (2)

aa375-C-term (2)

aa379-428 (2)

350-430 aa, C-terminal (1)

Tyr414 (1)

aa1-18 (1)

aa2-17 (1)

aa224-428 (1)

aa319-429 (1)

p424 (1)

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Publications

No (92)

Sample Type

Adherent Cell Cultures (2)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-GST (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

Select

IHC-plus™ HDAC3 Antibody (aa2-17) LS-B2032

(4.0) Rating

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (aa2-17) Antibody

Reactivity:

Human

Applications:

ChrIP, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ HDAC3 Antibody (clone 7G6C5) LS-B3894

(4.0) Rating

Antibody:

HDAC3 Mouse anti-Human Monoclonal (7G6C5) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

IHC-plus™ HDAC3 Antibody (aa224-428, clone 3A7B5) LS-B3893

(4.0) Rating

Antibody:

HDAC3 Mouse anti-Human Monoclonal (aa224-428) (3A7B5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

HDAC3 Antibody (phospho-Ser424) LS-C359014

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (pSer424) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

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Human HDAC3 (Sandwich ELISA) ELISA Kit - LS-F55924

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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HDAC3 Antibody (aa375-C-term) LS-C287353

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (aa375-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

HDAC3 Antibody (Amino Acid: 224-428, clone 7G6C5) LS-C758737

Antibody:

HDAC3 Mouse anti-Human Monoclonal (Amino Acid: 224-428) (7G6C5) Antibody

Reactivity:

Mouse, Rat, Non-Human Primate, Human

Applications:

ChIP-Seq, ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$541

Select

HDAC3 Antibody (C-Terminus) LS-C353111

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

HDAC3 Antibody (phospho-Ser424) LS-C800877

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (pSer424) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

HDAC3 Antibody (p424) LS-C822363

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (p424) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HDAC3 Antibody (phospho-Ser424) LS-C822366

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (pSer424) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HDAC3 Antibody LS-C826700

Antibody:

HDAC3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

HDAC3 Antibody LS-C331931

Antibody:

HDAC3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ChIP-Seq, ChrIP, IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

HDAC3 Antibody (aa1-428) LS-C369761

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (aa1-428) Antibody

Reactivity:

Human

Applications:

ChrIP, ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

HDAC3 Antibody LS-C416296

Antibody:

HDAC3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

HDAC3 Antibody (phospho-Ser424) LS-C416398

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (pSer424) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

HDAC3 Antibody LS-C417329

Antibody:

HDAC3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

HDAC3 Antibody (aa379-428) LS-C117905

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (aa379-428) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

HDAC3 Antibody (aa379-428) LS-C118479

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (aa379-428) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

HDAC3 Antibody (phospho-Ser424) LS-C199041

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (pSer424) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

HDAC3 Antibody (370-450 aa) LS-C381509

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (370-450 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HDAC3 Antibody (C-Terminus) LS-C7406

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

HDAC3 Antibody (350-430 aa, C-terminal) LS-C386101

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (350-430 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HDAC3 Antibody (370-450 aa) LS-C383902

Antibody:

HDAC3 Rabbit anti-Human Polyclonal (370-450 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HDAC3 Antibody (clone 3G6) LS-C827926

Antibody:

HDAC3 Mouse anti-Human Monoclonal (3G6) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$482

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