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HDAC2

histone deacetylase 2

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Gene Name: histone deacetylase 2
Family/Subfamily: Histone Deacetylase , not assigned-Histone Deacetylase
Synonyms: HDAC2, HD2, Histone deacetylase 2, RPD3, YAF1, YY1-associated factor 1
Target Sequences: NM_001527 NP_001518.3

Publications (1)

1
Epigenetic modifications induced by RGC-32 in colon cancer. Vlaicu SI, Tegla CA, Cudrici CD, Fosbrink M, Nguyen V, Azimzadeh P, Rus V, Chen H, Mircea PA, Shamsuddin A, Rus H. Experimental and molecular pathology. 2010 88:67-76. (WB) [PubMed:19883641] [PMC:PMC2815209]

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Antibodies (82)
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HDAC2 Antibody - Anti-HDAC2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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HDAC2 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HDAC2 Antibody - Anti-HDAC2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HDAC2 Rabbit anti-Human Polyclonal (aa419-468) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
HDAC2 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HDAC2 Rabbit anti-Human Polyclonal (aa464-478) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
HDAC2 Protein
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Baculovirus
His, C-Terminal
50 µg/$411; 250 µg/$985; 10 µg/$276
HDAC2 Antibody - HDAC2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
HDAC2 Antibody - Anti-HDAC2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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HDAC2 Rabbit anti-Human Polyclonal (aa360-409) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
HDAC2 Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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HDAC2 Rabbit anti-Human Polyclonal (aa410-439) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
HDAC2 Antibody - Immunohistochemistry of HDAC2 in rat testis tissue with HDAC2 antibody at 5 ug/mL.
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
HDAC2 Antibody - HeLa lysate run on 4-12 % Bis-Tris 2D gel in 1xMOPS running buffer. Transfer to 0.45 um nitrocellulose. Membrane probed with 3F3 (anti-HDAC2). Anti-mouse IgG (whole molecule)-AP conjugate (1 in 2000). Detection with BCIP/NBT substrate.
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HDAC2 Mouse anti-Human Monoclonal (3F3) Antibody
Mouse, Rat, Human
ChrIP, Flo, ICC, IF, IHC-P, IP, WB
Unconjugated
0.1 mg/$482
HDAC2 Antibody - 1:100 staining human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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HDAC2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ELISA, ICC, IF, WB
Unconjugated
100 µl/$688
HDAC2 Antibody - Western Blot of Rabbit Anti-HDAC2 antibody. Lane 1: mouse brain extract. Lane 2: mouse brain extract blocked with peptide. Load: 4 ug per lane. Primary antibody: HDAC2 antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 59 kDa for HDAC2.
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HDAC2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Primate, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$567
HDAC2 Antibody - Western Blot of Rabbit anti-HDAC2 antibody. Lane 1: mouse brain extract. Lane 2: mouse brain extract blocked with peptide. Load: 4 ug per lane. Primary antibody: HDAC2 antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 59 kDa for HDAC2. Other band(s): ~45kDa.
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HDAC2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Primate, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$567
HDAC2 Antibody - Anti-HDAC2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HDAC2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
HDAC2 Antibody - ICC/IF analysis of HDAC2 in HeLa cells. The cell was stained with HDAC2 antibody (1:100).The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
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HDAC2 Mouse anti-Human Monoclonal (AT3B1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
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HDAC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, IP, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HDAC2 Antibody - Anti-HDAC2 rabbit polyclonal antibody at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 53 kDa. Observed band size: 60 kDa.
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HDAC2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
Viewing 1-25 of 102 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).