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Anti-HAVCR1 / KIM-1 Antibody (clone RMT1-10) LS-C187571

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular HAVCR1 / KIM-1 Antibodies

Anti-HAVCR1 / KIM-1 Antibody (aa200-300) IHC-plus™ LS-B2031
Rabbit Polyclonal (IgG) to Human HAVCR1 / KIM-1
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-HAVCR1 / KIM-1 Antibody (N-Terminus) IHC-plus™ LS-B2103
Rabbit Polyclonal to Human HAVCR1 / KIM-1
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-HAVCR1 / KIM-1 Antibody (Internal) IHC-plus™ LS-B2463
Rabbit Polyclonal to Human HAVCR1 / KIM-1
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone RMT1-10] (IgG2a) to Mouse HAVCR1 / KIM-1
Mouse
Immunofluorescence, Flow Cytometry, ELISA (applications tested for the base form of this product only)
Unconjugated

Details

Mouse HAVCR1 / KIM-1
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [RMT1-10]
Unconjugated. Also available conjugated with FITC, RPE.
Protein G purified
Unmodified. Also available Low Endotoxin.

Applications

  • Immunofluorescence
  • Flow Cytometry
  • ELISA
  • (applications tested for the base form of this product only)

Specificity and Use

HAVCR1 / KIM-1 antibody was raised against full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Clone RMT1-10 specifically recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Clone RMT1-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies see for details. Clone RMT1-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies see for details.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About HAVCR1 / KIM-1

Q96D42 NM_012206 NP_036338.2

HAVCR1 Antibody, HAVCR-1 Antibody, KIM-1 Antibody, Kidney injury molecule 1 Antibody, KIM1 Antibody, T-cell membrane protein 1 Antibody, TIM1 Antibody, TIMD1 Antibody, TIM-1 Antibody, HAVCR Antibody, TIMD-1 Antibody

Hepatitis A Virus Cellular Receptor 1 (HAVCR1) is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. HAVCR1 may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals.

Flow Cytometry

Flow Cytometry
TIM-1 transfected NRK cells stained with Rat anti-Mouse TIM-1. This image was taken for the unmodified form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/10/2016

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