HAP1

huntingtin-associated protein 1

Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca2+ release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).

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Antibodies (40)

Proteins (7)

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Primary (40)

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HAP1 (48)

Reactivity

Human (22)

Mouse (13)

Rat (13)

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IHC (7)

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IHC-P (5)

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IgG (9)

IgG1 (1)

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monoclonal mc (1)

polyclonal pc (39)

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96-Well Strip Plate (1)

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APC Conjugated (4)

Biotin Conjugated (4)

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Unconjugated (14)

Epitope

aa132-328 (8)

aa160-381 (8)

aa349-584 (8)

aa469-480 (1)

aa562-573 (1)

aa639-653 (1)

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No (48)

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His-T7 (1)

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Rat (1)

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IHC-plus™ HAP1 Antibody LS-B1357

(4.0) Rating

Antibody:

HAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ HAP1 Antibody (aa469-480) LS-B8296

(4.0) Rating

Antibody:

HAP1 Goat anti-Human Polyclonal (aa469-480) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ HAP1 Antibody (aa639-653) LS-B813

(4.0) Rating

Antibody:

HAP1 Rabbit anti-Human Polyclonal (aa639-653) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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HAP1 Antibody (clone 1B6) LS-C141774

Antibody:

HAP1 Mouse anti-Rat Monoclonal (1B6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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HAP1 Antibody LS-C753890

Antibody:

HAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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HAP1 Antibody LS-C829414

Antibody:

HAP1 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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HAP1 Antibody LS-C778704

Antibody:

HAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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HAP1 Antibody (aa562-573) LS-C54959

Antibody:

HAP1 Goat anti-Mouse Polyclonal (aa562-573) Antibody

Reactivity:

Mouse, Rat

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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HAP1 Antibody (aa132-328) LS-C374934

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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HAP1 Antibody (aa132-328, HRP) LS-C714057

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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HAP1 Antibody (aa132-328, Biotin) LS-C689075

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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HAP1 Antibody (aa132-328, FITC) LS-C696139

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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HAP1 Antibody (aa132-328, APC, Cy7) LS-C737038

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

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HAP1 Antibody (aa132-328, Cy3) LS-C705044

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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HAP1 Antibody (aa132-328, PE) LS-C728130

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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HAP1 Antibody (aa132-328, APC) LS-C719224

Antibody:

HAP1 Rabbit anti-Mouse Polyclonal (aa132-328) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• HRP
• Biotin
• FITC
• APC, Cy7
• Cy3
• PE
• More...
  • APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC, Cy7
  • Cy3
  • PE
  • APC

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HAP1 Antibody LS-C310570

Antibody:

HAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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HAP1 Antibody (HRP) LS-C542463

Antibody:

HAP1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$937

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HAP1 Antibody (Biotin) LS-C522332

Antibody:

HAP1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

Select

HAP1 Antibody (FITC) LS-C532376

Antibody:

HAP1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$937

Select

HAP1 Antibody (PE) LS-C650574

Antibody:

HAP1 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$937

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HAP1 Antibody (APC) LS-C514116

Antibody:

HAP1 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$937

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

HAP1 Antibody (aa160-381) LS-C373623

Antibody:

HAP1 Rabbit anti-Human Polyclonal (aa160-381) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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HAP1 Antibody LS-C67194

Antibody:

HAP1 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Rat

Applications:

IHC

Format:

Unconjugated

Price:

100 µl/$688

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HAP1 Antibody LS-C816487

Antibody:

HAP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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